- The C-Scan® System consists of:
Single-use ingestible scanning capsule generates imaging data + positioning data
Single-use biocompatible unit tracks the capsule and records imaging data + positioning data
Standalone application processes and displays structural information
C-Scan’s technology is based on two physical phenomena relating to the interaction of X-ray photons with the contents of the colon and its tissue wall.
The first is X-ray fluorescence that occurs when X-ray photons interact with the ingested contrast agent that mixes with the colon contents. This interaction generates secondary X-ray fluorescence photons, some of which are back-scattered towards the capsule and are detected by the x-ray detectors.
The second type of interaction that the emitted photons undergo is Compton scattering, an inelastic interaction of X-ray photons with electrons of atoms in the colon wall and lumen. Some of the photons scattered by this mechanism head back in the direction of the capsule with an energy correlated to their angle of scatter.
The number of detected X-ray fluorescence photons and Compton back-scattered photons is correlated to the distance between the capsule and the colon wall. As the distance between the capsule and the colon wall increases, presence of content induces higher rates of X-ray fluorescence photons. At the same time, the content attenuates Compton back-scattered photons, hence decreasing the corresponding detection rate.
These two physical processes that are separately measured according to the energy of the detected photons, enable estimation of the distance from the capsule to the colon wall simultaneously with estimating the local iodine concentration.
This imaging technology also has the advantage of using ultra-low dose radiation due to the fact that the imaging target objects are within very close proximity to the capsule, hence a very low x-ray flux is required to obtain sufficient signal-to-noise ratio and good image quality.