How does Check-Cap's X-ray Radar technology work?

Check-Cap's imaging capsule contains a device that transmits X-rays, with minimal radiation, to the intestinal wall and back. The analysis of distances creates 3D images of the colon's internal surface, enabling the detection of clinically significant polyps with a high degree of sensitivity. Bowel cleansing is unnecessary, since X-ray technology, unlike optics, create 360-degree angular scans that can "see through" intestinal content.

Patients just swallow the capsule and continue their daily routine. The capsule will travel through the colon and be excreted excreted naturally, all while transmitting relevant data to an external device attached to the patient's back.

How many lives will Check-Cap impact?

Colorectal cancer is the Western world's second largest cancer killer. In the U.S. alone, the American Cancer Society estimates that approximately 136,000 people are diagnosed with CRC annually, with roughly 50,000 people dying from the disease. And the World Health Organization anticipates that by 2020, there will be nearly 160,000 cases in the U.S. and more than 1.6 million worldwide.

But with early screening, CRC is largely preventable and/or treatable. Though the number of colonoscopies performed has increased, many patients still avoid screening. According to a study by the Center for Disease Control (CDC), 42 million Americans over the age of 50 have not been screened, and it would take 10 years and 32,700 more GIs to screen the unscreened population with colonoscopies.

Check-Cap is designed to be a patient-friendly screening alternative for patients who are unwilling or unable to undergo a colonoscopy. The idea is that, with this technology, doctors can spend less time on screenings and more time with patients who need therapeutic colonoscopies.

How will Check-Cap's accuracy compare to alternative screenings?

Check-Cap is designed to detect clinically significant polyps with a high degree of sensitivity. Check-Cap's x-rays, unlike optic alternatives, produces 360-degree angular scans. These scans enable 3D imaging of colon surface, thus enabling detection of polyps, which protrude inward into the colon, through the detection of irregularities in the topography of the colon.

How can Check-Cap create an accurate image without colon preparation?

Check-Cap's imaging capsule contains a device that transmits X-rays, with minimal radiation, to the intestinal wall and back. Distances measured to colon wall are utilized to creates 3D images of the colon's internal surface, enabling the detection of clinically significant polyps with a high degree of sensitivity. Bowel cleansing is unnecessary because its x-rays create 360-degree angular scans that can "see through" intestinal content.

How much radiation is a patient exposed to with Check-Cap?

The Check-Cap capsule is designed to image the lining of colon. Therefore, the amount of x-rays required is lower than that of imaging systems operating from outside of the body. In addition, x-ray transmission only occurs while the capsule is in motion, limiting radiation exposure even more. As a result, total radiation exposure is minimal - equivalent to a chest-X-ray or 1/300 of a CTC (Virtual Colonoscopy) analysis.

How is Check-Cap likely to affect the current colorectal cancer screening market?

Check-Cap is designed to be a patient-friendly screening alternative for patients who are unwilling or unable to undergo a colonoscopy. The idea is that, with this technology, doctors can spend less time on screenings and more time with patients who need therapeutic colonoscopies.

How are physicians involved?

Our imaging system is intended to be prescribed to patients by physicians. Once prescribed, the patient will drink a small amount of a radio opaque contrast agent (such as barium sulfate or iodine) in the doctor's office as he/she swallows the capsule, which will enhance the contrast of the colon surface. Once the screening is complete, a physician will retrieve the data collected by the external receiver worn by the patient and utilize our data viewer software application to view 3D recreations of the colon. They will analyze the visualization to determine whether any anatomical anomalies are present on the surface of the colon and advise on next steps, as appropriate.

Is Check-Cap expected to detect polyps behind folds?

Check-Cap is designed to detect clinically significant polyps with a high degree of sensitivity. Check-Cap's x-rays, unlike optic alternatives, produce 360-degree angular scans. These scans are intended to enable identification of polyps, which protrude inward into the colon, through the detection of irregularities in the topography of the colon.

Is Check-Cap's test for everyone?

There are a few segments of the population who will likely not be able to use Check-Cap, including those who are unable to swallow any capsule, those who have a relatively narrow colon, and symptomatic patients who may be prescribed a colonoscopy.

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